| n |
|
141152 |
|
264007 |
496907 |
524039 |
| ncontrols |
0.0 |
2.0 [2.0, 2.0] |
0.0 |
2.0 [2.0, 2.0] |
0.0 [0.0, 0.0] |
0.0 [0.0, 0.0] |
| Time in hospital at index hospitalization (days)1 |
66.0 |
5.0 [3.0, 9.0] |
69.7 |
5.0 [3.0, 8.0] |
|
|
| Index year1 |
0.0 |
2017.0 [2011.0, 2022.0] |
0.0 |
2017.0 [2011.0, 2021.0] |
2013.0 [2006.0, 2019.0] |
2017.0 [2011.0, 2021.0] |
| Type of visit Index1 |
0.0 |
80486 (57.0) |
0.0 |
142443 (54.0) |
|
|
| LVEF (%)1 |
80.0 |
40.0 [30.0, 50.0] |
80.5 |
40.0 [30.0, 46.0] |
|
|
| LVEF (%)1 |
21.5 |
|
19.2 |
|
|
|
| ≥50 |
|
29371 (26.5) |
|
48118 (22.5) |
|
|
| 40-49 |
|
28109 (25.4) |
|
52513 (24.6) |
|
|
| 30-39 |
|
28527 (25.7) |
|
58130 (27.2) |
|
|
| <30 |
|
24856 (22.4) |
|
54665 (25.6) |
|
|
| LVEF (%)1 |
21.5 |
|
19.2 |
|
|
|
| HFrEF (<40) |
|
53383 (48.2) |
|
112795 (52.8) |
|
|
| HFmrEF (40-49) |
|
28109 (25.4) |
|
52513 (24.6) |
|
|
| HFpEF (≥50) |
|
29371 (26.5) |
|
48118 (22.5) |
|
|
| LVEF (%)1 |
9.2 |
|
7.1 |
|
|
|
| ≥50 |
|
33514 (26.1) |
|
55490 (22.6) |
|
|
| 40-49 |
|
33239 (25.9) |
|
61778 (25.2) |
|
|
| 30-39 |
|
33339 (26.0) |
|
67092 (27.4) |
|
|
| <30 |
|
28131 (21.9) |
|
60830 (24.8) |
|
|
| Sex Male1 |
0.0 |
87791 (62.2) |
0.0 |
170620 (64.6) |
267515 (53.8) |
338564 (64.6) |
| Age (years)1 |
0.0 |
77.0 [68.0, 84.0] |
0.0 |
76.0 [67.0, 82.0] |
79.0 [71.0, 86.0] |
76.0 [67.0, 82.0] |
| Civil status Single1 |
28.4 |
44353 (43.9) |
27.5 |
78882 (41.2) |
|
|
| Living conditions Own home1 |
41.3 |
78794 (95.1) |
40.4 |
151752 (96.4) |
|
|
| Location In-patient1 |
0.0 |
48040 (34.0) |
0.0 |
79915 (30.3) |
|
|
| Smoking1 |
28.3 |
|
24.9 |
|
|
|
| Current |
|
10717 (10.6) |
|
20885 (10.5) |
|
|
| Former |
|
44507 (44.0) |
|
89057 (44.9) |
|
|
| Never |
|
45996 (45.4) |
|
88311 (44.5) |
|
|
| Smoking1 |
28.3 |
10717 (10.6) |
24.9 |
20885 (10.5) |
|
|
| Alcohol Risk1 |
41.7 |
3673 (4.5) |
38.1 |
7017 (4.3) |
|
|
| Duration of HF (months) ≥61 |
2.7 |
84111 (61.2) |
2.4 |
157601 (61.2) |
|
|
| Primary etiology1 |
39.1 |
|
38.1 |
|
|
|
| DCM |
|
5515 (6.4) |
|
13019 (8.0) |
|
|
| Heart valve disease |
|
6690 (7.8) |
|
11857 (7.3) |
|
|
| Hypertension |
|
22147 (25.8) |
|
40444 (24.7) |
|
|
| IHD |
|
31935 (37.1) |
|
63137 (38.6) |
|
|
| Known alcoholic cardiomyopathy |
|
577 (0.7) |
|
1166 (0.7) |
|
|
| Other |
|
19139 (22.3) |
|
33809 (20.7) |
|
|
| NYHA class1 |
28.7 |
|
24.4 |
|
|
|
| I |
|
14532 (14.4) |
|
26528 (13.3) |
|
|
| II |
|
47303 (47.0) |
|
97571 (48.9) |
|
|
| III |
|
35273 (35.0) |
|
69984 (35.1) |
|
|
| IV |
|
3564 (3.5) |
|
5454 (2.7) |
|
|
| NYHA class III-IV1 |
28.7 |
38837 (38.6) |
24.4 |
75438 (37.8) |
|
|
| Killip class1 |
93.5 |
|
95.2 |
|
|
|
| Chock or hypertension |
|
28 (0.3) |
|
53 (0.4) |
|
|
| Edema |
|
247 (2.7) |
|
337 (2.7) |
|
|
| No signs of HF |
|
4327 (47.5) |
|
6251 (49.2) |
|
|
| Rales or crackles |
|
4507 (49.5) |
|
6059 (47.7) |
|
|
| Weight (kg)1 |
15.6 |
77.6 [66.2, 90.0] |
14.4 |
79.0 [68.0, 92.0] |
|
|
| Weight at admission/visit (kg)1 |
31.8 |
78.0 [67.0, 91.0] |
34.4 |
79.5 [68.0, 92.0] |
|
|
| Weight at discharge (hospitalized patients) (kg)1 |
93.7 |
75.2 [63.7, 88.5] |
95.3 |
76.8 [65.0, 90.0] |
|
|
| Height (cm)1 |
28.5 |
172.0 [165.0, 179.0] |
23.4 |
173.0 [165.0, 180.0] |
|
|
| Systolic blood pressure (mmHg)1 |
4.8 |
125.0 [110.0, 140.0] |
4.2 |
124.0 [110.0, 140.0] |
|
|
| shf_bpsys_cat ≥1401 |
4.4 |
36974 (27.4) |
3.9 |
67652 (26.7) |
|
|
| Systolic blood pressure at admission/visit (mmHg)1 |
21.8 |
125.0 [111.0, 140.0] |
25.4 |
125.0 [110.0, 140.0] |
|
|
| Systolic blood pressure at discharge (hospitalized patients) (mmHg)1 |
92.9 |
125.0 [111.0, 140.0] |
94.8 |
124.0 [110.0, 140.0] |
|
|
| Diastolic blood pressure (mmHg)1 |
4.7 |
70.0 [65.0, 80.0] |
4.1 |
70.0 [65.0, 80.0] |
|
|
| Diastolic blood pressure at admission/visit (mmHg)1 |
21.7 |
72.0 [65.0, 80.0] |
25.4 |
73.0 [65.0, 80.0] |
|
|
| Diastolic blood pressure at discharge (hospitalized patients) (mmHg)1 |
92.9 |
72.0 [65.0, 80.0] |
94.8 |
72.0 [65.0, 80.0] |
|
|
| Mean arterial pressure (mmHg)1 |
4.7 |
90.0 [81.7, 99.0] |
4.1 |
90.0 [81.7, 98.7] |
|
|
| Mean arterial pressure (mmHg) >901 |
4.7 |
63756 (47.4) |
4.1 |
119827 (47.3) |
|
|
| Heart rate (beats/min)1 |
7.3 |
71.0 [62.0, 81.0] |
6.5 |
70.0 [62.0, 80.0] |
|
|
| Heart rate at admission/visit (beats/min)1 |
23.7 |
71.0 [62.0, 83.0] |
27.1 |
71.0 [62.0, 82.0] |
|
|
| Heart rate at discharge (hospitalized patients) (beats/min)1 |
93.0 |
74.0 [65.0, 85.0] |
94.8 |
74.0 [65.0, 85.0] |
|
|
| Heart rate (beats/min) >701 |
7.3 |
66023 (50.4) |
6.5 |
122427 (49.6) |
|
|
| Hemoglobin (g/L)1 |
10.1 |
132.0 [119.0, 144.0] |
10.1 |
133.0 [121.0, 145.0] |
|
|
| Hemoglobin at admission/visit (g/L)1 |
27.0 |
133.0 [120.0, 145.0] |
31.0 |
134.0 [122.0, 146.0] |
|
|
| Hemoglobin at discharge (hospitalized patients) (g/L)1 |
95.3 |
120.0 [106.0, 135.0] |
96.5 |
122.0 [108.0, 138.0] |
|
|
| Anemia1 |
10.1 |
45483 (35.8) |
10.1 |
78797 (33.2) |
|
|
| Potassium (mmol/L)1 |
17.7 |
4.2 [3.9, 4.5] |
16.2 |
4.2 [4.0, 4.5] |
|
|
| Potassium at admission/visit (mmol/L)1 |
30.6 |
4.2 [3.9, 4.5] |
32.9 |
4.2 [4.0, 4.5] |
|
|
| Potassium at discharge (hospitalized patients) (mmol/L)1 |
93.6 |
4.0 [3.7, 4.3] |
95.3 |
4.0 [3.7, 4.3] |
|
|
| Potassium (mmol/L)1 |
17.7 |
|
16.2 |
|
|
|
| 3.5-5 (Normakalemia) |
|
106763 (91.9) |
|
205177 (92.8) |
|
|
| <3.5 (Hypokalemia) |
|
4877 (4.2) |
|
7817 (3.5) |
|
|
| >5 (Hyperkalemia) |
|
4560 (3.9) |
|
8202 (3.7) |
|
|
| Sodium (mmol/L)1 |
30.0 |
140.0 [138.0, 142.0] |
29.4 |
140.0 [138.0, 142.0] |
|
|
| Sodium at admission/visit (mmol/L)1 |
39.5 |
140.0 [138.0, 142.0] |
41.5 |
140.0 [138.0, 142.0] |
|
|
| Sodium at discharge (hospitalized patients) (mmol/L)1 |
93.7 |
140.0 [138.0, 142.0] |
95.4 |
140.0 [138.0, 142.0] |
|
|
| Creatinine (µmol/L)1 |
4.1 |
97.0 [79.0, 124.0] |
3.8 |
96.0 [79.0, 122.0] |
|
|
| Creatinine at admission/visit (µmol/L)1 |
21.3 |
95.0 [78.0, 121.0] |
25.1 |
94.0 [77.0, 117.0] |
|
|
| Creatinine at discharge (hospitalized patients) (µmol/L)1 |
93.5 |
99.0 [78.0, 132.0] |
95.2 |
96.0 [77.0, 126.0] |
|
|
| eGFR (mL/min/1.73 m²)1 |
3.9 |
63.3 [45.5, 82.9] |
3.5 |
65.2 [47.6, 84.2] |
|
|
| eGFR (mL/min/1.73 m²) <601 |
3.9 |
61395 (45.2) |
3.5 |
108179 (42.5) |
|
|
| NT-proBNP (pg/mL)1 |
39.7 |
1866.0 [696.0, 4498.0] |
38.7 |
1752.0 [682.0, 4070.0] |
|
|
| NT-proBNP at admission/visit (pg/mL)1 |
48.3 |
1768.0 [655.0, 4237.0] |
49.4 |
1650.0 [636.0, 3816.0] |
|
|
| NT-proBNP at discharge (hospitalized patients) (pg/mL)1 |
97.4 |
3650.0 [1629.0, 8430.8] |
98.0 |
3350.0 [1490.0, 7371.0] |
|
|
| BNP (pg/mL)1 |
96.4 |
590.0 [227.0, 1363.0] |
96.1 |
530.0 [203.0, 1246.0] |
|
|
| Transferrin saturation (%)1 |
82.9 |
24.0 [17.0, 33.0] |
83.2 |
25.0 [17.0, 33.0] |
|
|
| Ferritin (µg/L)1 |
80.8 |
143.0 [71.0, 270.0] |
81.1 |
142.0 [70.0, 265.0] |
|
|
| QRS width (ms)1 |
22.2 |
104.0 [92.0, 134.0] |
22.2 |
106.0 [92.0, 136.0] |
|
|
| Left Bundle Branch Block (LBBB)1 |
23.2 |
18723 (17.3) |
23.5 |
37214 (18.4) |
|
|
| Loop diuretic IV1 |
76.1 |
8029 (23.8) |
76.1 |
11290 (17.9) |
|
|
| Ferric carboxymaltose IV1 |
46.2 |
4329 (5.7) |
47.0 |
7440 (5.3) |
|
|
| Ferric carboxymaltose IV dose (mg)1 |
97.1 |
1000.0 [1000.0, 1000.0] |
97.3 |
1000.0 [1000.0, 1000.0] |
|
|
| Unplanned inotrope support1 |
49.0 |
1448 (2.0) |
51.1 |
3843 (3.0) |
|
|
| Diuretic1 |
0.6 |
102923 (73.3) |
0.4 |
192949 (73.4) |
|
|
| Loop diuretic1 |
22.1 |
76229 (69.3) |
21.8 |
142521 (69.1) |
|
|
| Loop diuretic substance1 |
66.6 |
|
68.1 |
|
|
|
| Bumetanid |
|
294 (0.6) |
|
449 (0.5) |
|
|
| Furosemid |
|
46597 (98.9) |
|
83387 (99.0) |
|
|
| Toresamid |
|
223 (0.5) |
|
369 (0.4) |
|
|
| Loop diuretic dose (mg/24h)1 |
57.0 |
40.0 [40.0, 80.0] |
57.0 |
40.0 [40.0, 80.0] |
|
|
| Loop diuretic usage When necessary1 |
46.1 |
18190 (23.9) |
46.1 |
34788 (24.5) |
|
|
| ACEi1 |
0.5 |
62205 (44.3) |
0.4 |
121916 (46.3) |
|
|
| ACEi dose (mg/24h)1 |
56.0 |
10.0 [5.0, 15.0] |
53.9 |
10.0 [5.0, 15.0] |
|
|
| ARB1 |
0.9 |
39696 (28.4) |
0.8 |
77865 (29.7) |
|
|
| ARB dose (mg/24h)1 |
71.9 |
32.0 [12.0, 50.0] |
70.6 |
32.0 [12.0, 50.0] |
|
|
| ARNi1 |
45.0 |
13818 (17.8) |
45.9 |
26743 (18.7) |
|
|
| ACEi/ARB/ARNi1 |
1.1 |
113943 (81.6) |
0.9 |
222758 (85.1) |
|
|
| Beta-blocker1 |
0.4 |
121329 (86.3) |
0.3 |
231563 (88.0) |
|
|
| Beta-blocker dose (mg/24h)1 |
14.2 |
25.0 [5.0, 100.0] |
12.5 |
25.0 [5.0, 100.0] |
|
|
| MRA1 |
0.7 |
59245 (42.3) |
0.5 |
113903 (43.4) |
|
|
| MRA dose (mg/24h)1 |
68.0 |
25.0 [25.0, 25.0] |
67.8 |
25.0 [25.0, 25.0] |
|
|
| Digoxin1 |
0.5 |
16498 (11.7) |
0.4 |
31209 (11.9) |
|
|
| Platelet inhibitor1 |
0.6 |
51214 (36.5) |
0.4 |
95602 (36.4) |
|
|
| Oral anticoagulant1 |
0.5 |
67996 (48.4) |
0.4 |
130980 (49.8) |
|
|
| Statin1 |
0.5 |
67613 (48.1) |
0.4 |
132984 (50.6) |
|
|
| Nitrate1 |
0.6 |
16371 (11.7) |
0.4 |
29657 (11.3) |
|
|
| SGLT2i1 |
70.7 |
25433 (61.4) |
74.4 |
40168 (59.5) |
|
|
| SGLT2i dose (mg/24h)1 |
82.0 |
10.0 [10.0, 10.0] |
84.8 |
10.0 [10.0, 10.0] |
|
|
| Sinus node inhibitor1 |
46.8 |
319 (0.4) |
48.0 |
666 (0.5) |
|
|
| Device therapy1 |
1.2 |
|
1.4 |
|
|
|
| No |
|
115445 (82.7) |
|
210541 (80.9) |
|
|
| Pacemaker |
|
12714 (9.1) |
|
23383 (9.0) |
|
|
| CRT-P |
|
2685 (1.9) |
|
5689 (2.2) |
|
|
| CRT-D |
|
4177 (3.0) |
|
10181 (3.9) |
|
|
| ICD |
|
4500 (3.2) |
|
10491 (4.0) |
|
|
| Device therapy CRT/ICD1 |
1.2 |
11362 (8.1) |
1.4 |
26361 (10.1) |
|
|
| Chest X-ray1 |
41.8 |
|
40.4 |
|
|
|
| No |
|
25272 (30.7) |
|
51253 (32.6) |
|
|
| Normal |
|
19301 (23.5) |
|
36348 (23.1) |
|
|
| Pulmonary congestion |
|
10399 (12.7) |
|
18045 (11.5) |
|
|
| Cardiomegaly |
|
12521 (15.2) |
|
24849 (15.8) |
|
|
| Pulmonary congestion & cardiomegaly |
|
14701 (17.9) |
|
26936 (17.1) |
|
|
| Diabetes1 |
8.4 |
24041 (18.6) |
7.8 |
47141 (19.4) |
|
|
| Diabetes1 |
23.2 |
|
22.7 |
|
|
|
| No |
|
86322 (79.7) |
|
161764 (79.3) |
|
|
| Type I |
|
1608 (1.5) |
|
2926 (1.4) |
|
|
| Type II |
|
20428 (18.9) |
|
39317 (19.3) |
|
|
| Hypertension1 |
2.0 |
80618 (58.3) |
1.9 |
148080 (57.2) |
|
|
| Atrial fibrillation/flutter1 |
0.6 |
72858 (51.9) |
0.5 |
133931 (51.0) |
|
|
| Lung disease1 |
1.9 |
24039 (17.4) |
1.8 |
43301 (16.7) |
|
|
| Valve disease1 |
3.0 |
26617 (19.4) |
3.0 |
49341 (19.3) |
|
|
| Dilated cardiomyopathy1 |
4.2 |
13006 (9.6) |
4.3 |
30392 (12.0) |
|
|
| Revascularization1 |
2.7 |
35989 (26.2) |
2.8 |
71926 (28.0) |
|
|
| Valve surgery1 |
1.8 |
9205 (6.6) |
2.0 |
17958 (6.9) |
|
|
| ECG rythm1 |
9.3 |
|
9.0 |
|
|
|
| Sinus |
|
65595 (51.2) |
|
124231 (51.7) |
|
|
| Atrial fibrillation |
|
47169 (36.8) |
|
85476 (35.6) |
|
|
| PM/Other |
|
15321 (12.0) |
|
30636 (12.7) |
|
|
| Follow-up referral HF nurse clinic1 |
9.7 |
74462 (58.4) |
6.8 |
165842 (67.4) |
|
|
| Follow-up referral speciality1 |
7.6 |
|
5.3 |
|
|
|
| Hospital |
|
80027 (61.4) |
|
166755 (66.7) |
|
|
| Primary care |
|
44760 (34.3) |
|
74611 (29.8) |
|
|
| Other |
|
5628 (4.3) |
|
8749 (3.5) |
|
|
| Follow-up referral speciality Hospital1 |
7.6 |
80027 (61.4) |
5.3 |
166755 (66.7) |
|
|
| EQ5D-vas1 |
66.0 |
70.0 [50.0, 80.0] |
64.2 |
70.0 [50.0, 80.0] |
|
|
| EQ5D-vas1 |
66.0 |
|
64.2 |
|
|
|
| 0-25 |
|
2140 (4.5) |
|
3953 (4.2) |
|
|
| 26-50 |
|
11847 (24.7) |
|
22636 (24.0) |
|
|
| 51-75 |
|
19403 (40.4) |
|
38762 (41.0) |
|
|
| 76-100 |
|
14582 (30.4) |
|
29133 (30.8) |
|
|
| Fatigue1 |
56.1 |
|
54.0 |
|
|
|
| At rest |
|
3662 (5.9) |
|
6268 (5.2) |
|
|
| At moderate effort |
|
16410 (26.5) |
|
30851 (25.4) |
|
|
| At more than moderate effort |
|
30809 (49.7) |
|
63346 (52.2) |
|
|
| Unaffected |
|
11079 (17.9) |
|
20921 (17.2) |
|
|
| Out of breath1 |
55.6 |
|
53.5 |
|
|
|
| At rest |
|
1904 (3.0) |
|
3050 (2.5) |
|
|
| At moderate effort |
|
17914 (28.6) |
|
33837 (27.6) |
|
|
| At more than moderate effort |
|
32432 (51.7) |
|
66509 (54.2) |
|
|
| Unaffected |
|
10433 (16.6) |
|
19264 (15.7) |
|
|
| Mobilty1 |
55.5 |
|
53.5 |
|
|
|
| Bedridden |
|
705 (1.1) |
|
998 (0.8) |
|
|
| Some problem |
|
27447 (43.7) |
|
50643 (41.3) |
|
|
| No problem |
|
34683 (55.2) |
|
71003 (57.9) |
|
|
| Hygiene1 |
56.0 |
|
54.0 |
|
|
|
| Can't wash and clothe |
|
1128 (1.8) |
|
1580 (1.3) |
|
|
| Some problem |
|
6905 (11.1) |
|
11236 (9.3) |
|
|
| No problem |
|
54055 (87.1) |
|
108637 (89.4) |
|
|
| Main activities1 |
56.2 |
|
54.2 |
|
|
|
| Can't do |
|
2973 (4.8) |
|
4798 (4.0) |
|
|
| Some problem |
|
16085 (26.0) |
|
29836 (24.7) |
|
|
| No problem |
|
42699 (69.1) |
|
86233 (71.3) |
|
|
| Pain1 |
58.1 |
|
56.0 |
|
|
|
| Severe |
|
3737 (6.3) |
|
6733 (5.8) |
|
|
| Moderate |
|
26707 (45.1) |
|
52295 (45.0) |
|
|
| None |
|
28728 (48.5) |
|
57256 (49.2) |
|
|
| Anxiety/Depression1 |
59.8 |
|
57.7 |
|
|
|
| Severe |
|
2346 (4.1) |
|
4269 (3.8) |
|
|
| Moderate |
|
20667 (36.4) |
|
40340 (36.1) |
|
|
| None |
|
33708 (59.4) |
|
67001 (60.0) |
|
|
| BMI (kg/m²)1 |
37.6 |
26.3 [23.2, 30.1] |
32.5 |
26.7 [23.6, 30.5] |
|
|
| BMI (kg/m²) ≥301 |
37.6 |
23043 (26.1) |
32.4 |
49835 (27.9) |
|
|
| Target dose beta-blocker (%)1 |
14.2 |
50.0 [25.0, 100.0] |
12.5 |
50.0 [25.0, 100.0] |
|
|
| Target dose beta-blocker (%)1 |
0.6 |
|
0.5 |
|
|
|
| 0 |
|
19201 (13.7) |
|
31570 (12.0) |
|
|
| 1-49 |
|
43817 (31.2) |
|
81548 (31.1) |
|
|
| 50-99 |
|
42315 (30.2) |
|
81584 (31.1) |
|
|
| ≥100 |
|
34905 (24.9) |
|
67881 (25.9) |
|
|
| Target dose MRA (%)1 |
68.0 |
50.0 [50.0, 50.0] |
67.8 |
50.0 [50.0, 50.0] |
|
|
| Target dose MRA (%)1 |
10.7 |
|
11.4 |
|
|
|
| 0 |
|
80892 (64.2) |
|
148685 (63.6) |
|
|
| 1-49 |
|
5218 (4.1) |
|
10118 (4.3) |
|
|
| 50-99 |
|
31052 (24.6) |
|
59049 (25.3) |
|
|
| ≥100 |
|
8902 (7.1) |
|
15952 (6.8) |
|
|
| Target dose ACEi (%)1 |
56.0 |
50.0 [25.0, 75.0] |
53.9 |
50.0 [25.0, 75.0] |
|
|
| Target dose ACEi (%)1 |
0.6 |
|
0.4 |
|
|
|
| 0 |
|
78265 (55.8) |
|
141124 (53.7) |
|
|
| 1-49 |
|
25411 (18.1) |
|
47433 (18.0) |
|
|
| 50-99 |
|
22676 (16.2) |
|
45194 (17.2) |
|
|
| ≥100 |
|
14005 (10.0) |
|
29081 (11.1) |
|
|
| Target dose ARB (%)1 |
71.9 |
50.0 [25.0, 75.0] |
70.6 |
50.0 [25.0, 75.0] |
|
|
| Target dose ARB (%)1 |
1.0 |
|
0.8 |
|
|
|
| 0 |
|
100140 (71.7) |
|
184152 (70.3) |
|
|
| 1-49 |
|
17648 (12.6) |
|
33855 (12.9) |
|
|
| 50-99 |
|
12508 (8.9) |
|
25014 (9.6) |
|
|
| ≥100 |
|
9465 (6.8) |
|
18863 (7.2) |
|
|
| Target dose ARNi (%)1 |
90.2 |
75.0 [50.0, 100.0] |
89.9 |
62.0 [50.0, 100.0] |
|
|
| Target dose ARNi (%)1 |
45.0 |
|
45.9 |
|
|
|
| 0 |
|
63908 (82.3) |
|
116173 (81.4) |
|
|
| 1-49 |
|
3001 (3.9) |
|
5970 (4.2) |
|
|
| 50-99 |
|
4192 (5.4) |
|
8632 (6.0) |
|
|
| ≥100 |
|
6542 (8.4) |
|
12007 (8.4) |
|
|
| Target dose ACEi/ARB/ARNi (%)1 |
19.0 |
50.0 [25.0, 100.0] |
15.3 |
50.0 [25.0, 100.0] |
|
|
| Target dose ACEi/ARB/ARNi (%)1 |
0.7 |
|
0.6 |
|
|
|
| 0 |
|
25751 (18.4) |
|
39029 (14.9) |
|
|
| 1-49 |
|
45474 (32.5) |
|
85890 (32.7) |
|
|
| 50-99 |
|
39007 (27.8) |
|
77930 (29.7) |
|
|
| ≥100 |
|
29878 (21.3) |
|
59648 (22.7) |
|
|
| Age (years)1 |
0.0 |
|
0.0 |
|
|
|
| <70 |
|
38459 (27.2) |
|
82175 (31.1) |
113409 (22.8) |
164154 (31.3) |
| 70-80 |
|
49555 (35.1) |
|
97749 (37.0) |
154623 (31.1) |
194340 (37.1) |
| >80 |
|
53138 (37.6) |
|
84083 (31.8) |
228875 (46.1) |
165545 (31.6) |
| Previous HFH < 1 year12 |
0.0 |
75065 (53.2) |
0.0 |
132479 (50.2) |
324616 (65.3) |
0 (0.0) |
| Atrial fibrillation/flutter12 |
0.0 |
82869 (58.7) |
0.0 |
151976 (57.6) |
224001 (45.1) |
40830 (7.8) |
| IHD12 |
0.0 |
73115 (51.8) |
0.0 |
138075 (52.3) |
219241 (44.1) |
73267 (14.0) |
| Hypertension12 |
0.0 |
97059 (68.8) |
0.0 |
177938 (67.4) |
267679 (53.9) |
120276 (23.0) |
| Diabetes12 |
0.0 |
38352 (27.2) |
0.0 |
72171 (27.3) |
114850 (23.1) |
44974 (8.6) |
| Valve disease12 |
0.0 |
36909 (26.1) |
0.0 |
68339 (25.9) |
78282 (15.8) |
12922 (2.5) |
| Marital status Single/widowed/divorced3 |
0.1 |
76455 (54.2) |
0.1 |
137894 (52.3) |
289107 (58.3) |
247315 (47.2) |
| Family situation Living alone3 |
0.1 |
70785 (50.2) |
0.1 |
126312 (47.9) |
271654 (54.8) |
226314 (43.2) |
| Education3 |
2.1 |
|
1.9 |
|
|
|
| Compulsory school |
|
57396 (41.5) |
|
104152 (40.2) |
231508 (48.5) |
182146 (35.4) |
| Secondary school |
|
55183 (39.9) |
|
105726 (40.8) |
171254 (35.9) |
201291 (39.1) |
| University |
|
25677 (18.6) |
|
48997 (18.9) |
74211 (15.6) |
131106 (25.5) |
| Disposable income (100 SEK)3 |
0.1 |
1653.0 [1284.0, 2296.0] |
0.1 |
1662.0 [1294.0, 2333.0] |
1448.0 [1099.0, 1951.0] |
1783.0 [1341.0, 2709.0] |
| Duration of HF (days)2 |
0.0 |
301.0 [17.0, 1720.0] |
0.0 |
326.0 [20.0, 1843.0] |
0.0 [0.0, 99.0] |
|
| Time since last HF hospitalization (days)2 |
43.9 |
27.0 [0.0, 324.0] |
44.1 |
32.0 [0.0, 372.0] |
0.0 [0.0, 0.0] |
|
| Location2 |
0.0 |
|
0.0 |
|
|
|
| HF in-patient |
|
31556 (22.4) |
|
54530 (20.7) |
324616 (65.3) |
|
| Other in-patient |
|
17695 (12.5) |
|
27315 (10.3) |
17962 (3.6) |
|
| Out-patient |
|
91901 (65.1) |
|
182162 (69.0) |
154329 (31.1) |
|
| Hypertension2 |
0.0 |
84591 (59.9) |
0.0 |
153610 (58.2) |
267679 (53.9) |
120276 (23.0) |
| Diabetes2 |
0.0 |
36652 (26.0) |
0.0 |
68562 (26.0) |
114850 (23.1) |
44974 (8.6) |
| Ischemic heart disease2 |
0.0 |
71660 (50.8) |
0.0 |
135190 (51.2) |
217133 (43.7) |
72757 (13.9) |
| Myocardial infarction2 |
0.0 |
52181 (37.0) |
0.0 |
98630 (37.4) |
148639 (29.9) |
40059 (7.6) |
| Angina pectoris2 |
0.0 |
24585 (17.4) |
0.0 |
47154 (17.9) |
83916 (16.9) |
21562 (4.1) |
| PCI2 |
0.0 |
27912 (19.8) |
0.0 |
54882 (20.8) |
59259 (11.9) |
25870 (4.9) |
| CABG2 |
0.0 |
35470 (25.1) |
0.0 |
70157 (26.6) |
79613 (16.0) |
31010 (5.9) |
| Dilated cardiomyopathy2 |
0.0 |
11890 (8.4) |
0.0 |
27811 (10.5) |
15386 (3.1) |
0 (0.0) |
| Peripheral artery disease2 |
0.0 |
13479 (9.5) |
0.0 |
23695 (9.0) |
41084 (8.3) |
14366 (2.7) |
| Atrial fibrillation/flutter2 |
0.0 |
77190 (54.7) |
0.0 |
141039 (53.4) |
224001 (45.1) |
40830 (7.8) |
| Stroke2 |
0.0 |
21620 (15.3) |
0.0 |
37495 (14.2) |
81379 (16.4) |
44091 (8.4) |
| TIA2 |
0.0 |
4925 (3.5) |
0.0 |
8715 (3.3) |
17977 (3.6) |
11411 (2.2) |
| Stroke/TIA2 |
0.0 |
24668 (17.5) |
0.0 |
43011 (16.3) |
92463 (18.6) |
52161 (10.0) |
| Valvular disease2 |
0.0 |
29319 (20.8) |
0.0 |
53525 (20.3) |
78282 (15.8) |
12922 (2.5) |
| Renal failure2 |
0.0 |
21966 (15.6) |
0.0 |
37412 (14.2) |
57184 (11.5) |
11020 (2.1) |
| Dialysis2 |
0.0 |
1333 (0.9) |
0.0 |
2174 (0.8) |
5306 (1.1) |
810 (0.2) |
| Hyperkalemia2 |
0.0 |
3246 (2.3) |
0.0 |
5560 (2.1) |
6294 (1.3) |
892 (0.2) |
| Hypokalemia2 |
0.0 |
4426 (3.1) |
0.0 |
7245 (2.7) |
14047 (2.8) |
3245 (0.6) |
| COPD2 |
0.0 |
19262 (13.6) |
0.0 |
34460 (13.1) |
60250 (12.1) |
14927 (2.8) |
| Pneumonia/Flue/Respiratory infection2 |
0.0 |
50414 (35.7) |
0.0 |
90227 (34.2) |
177582 (35.7) |
49530 (9.5) |
| Liver disease2 |
0.0 |
3345 (2.4) |
0.0 |
6086 (2.3) |
9946 (2.0) |
3596 (0.7) |
| Obstructive sleep apnea2 |
0.0 |
6629 (4.7) |
0.0 |
13189 (5.0) |
14157 (2.8) |
8255 (1.6) |
| Dementia2 |
0.0 |
3410 (2.4) |
0.0 |
4374 (1.7) |
21422 (4.3) |
14476 (2.8) |
| Depression2 |
0.0 |
5153 (3.7) |
0.0 |
9220 (3.5) |
17785 (3.6) |
10678 (2.0) |
| Malignant cancer2 |
0.0 |
19242 (13.6) |
0.0 |
34006 (12.9) |
66269 (13.3) |
56770 (10.8) |
| Muscoloskeletal diseases2 |
0.0 |
45883 (32.5) |
0.0 |
83738 (31.7) |
149216 (30.0) |
108216 (20.7) |
| Alcohol abuse2 |
0.0 |
4721 (3.3) |
0.0 |
8722 (3.3) |
13535 (2.7) |
7375 (1.4) |
| Severe bleeding2 |
0.0 |
27797 (19.7) |
0.0 |
48465 (18.4) |
86824 (17.5) |
36999 (7.1) |
| Charlson Comorbidity Index2 |
0.0 |
3.0 [2.0, 4.0] |
0.0 |
3.0 [1.0, 4.0] |
2.0 [1.0, 4.0] |
0.0 [0.0, 2.0] |
| Charlson Comorbidity Index age-adjusted2 |
0.0 |
6.0 [4.0, 8.0] |
0.0 |
6.0 [4.0, 7.0] |
6.0 [5.0, 7.0] |
4.0 [2.0, 5.0] |
| Charlson Comorbidity Index2 |
0.0 |
|
0.0 |
|
|
|
| 0-1 |
|
34754 (24.6) |
|
68679 (26.0) |
136201 (27.4) |
378914 (72.3) |
| 2-3 |
|
56105 (39.7) |
|
107150 (40.6) |
207463 (41.8) |
115203 (22.0) |
| 4-7 |
|
44008 (31.2) |
|
77903 (29.5) |
136474 (27.5) |
27918 (5.3) |
| ≥8 |
|
6285 (4.5) |
|
10275 (3.9) |
16769 (3.4) |
2004 (0.4) |
| Heart failure hospitalization2 |
0.0 |
38323 (27.2) |
0.0 |
94441 (35.8) |
169125 (34.0) |
0 (0.0) |
| Number of heart failure hospitalizations2 |
0.0 |
0.0 [0.0, 1.0] |
0.0 |
0.0 [0.0, 1.0] |
0.0 [0.0, 1.0] |
0.0 [0.0, 0.0] |
| Any hospitalization2 |
0.0 |
97717 (69.2) |
0.0 |
195531 (74.1) |
376433 (75.8) |
277175 (52.9) |
| CV hospitalization2 |
0.0 |
63793 (45.2) |
0.0 |
139362 (52.8) |
262490 (52.8) |
97609 (18.6) |
| Non-CV hospitalization2 |
0.0 |
79399 (56.3) |
0.0 |
158930 (60.2) |
311570 (62.7) |
247712 (47.3) |
| Stroke/TIA hospitalization2 |
0.0 |
10449 (7.4) |
0.0 |
20765 (7.9) |
46354 (9.3) |
38635 (7.4) |
| Myocardial infarction hospitalization2 |
0.0 |
6967 (4.9) |
0.0 |
14985 (5.7) |
38004 (7.6) |
16626 (3.2) |
| Ischemic heart disease hospitalization2 |
0.0 |
12212 (8.7) |
0.0 |
28359 (10.7) |
61230 (12.3) |
23920 (4.6) |
| Ventricular fibrillation/tachycardia hospitalization2 |
0.0 |
1794 (1.3) |
0.0 |
5523 (2.1) |
5846 (1.2) |
416 (0.1) |
| Pneumonia/Flue/Respiratory infection hospitalization2 |
0.0 |
23986 (17.0) |
0.0 |
49339 (18.7) |
105449 (21.2) |
42797 (8.2) |
| Pneumonia hospitalization2 |
0.0 |
16125 (11.4) |
0.0 |
33361 (12.6) |
69625 (14.0) |
32107 (6.1) |
| Acute renal failure hospitalization2 |
0.0 |
7176 (5.1) |
0.0 |
15481 (5.9) |
25281 (5.1) |
6312 (1.2) |
| End-stage renal failure2 |
0.0 |
2635 (1.9) |
0.0 |
5460 (2.1) |
10397 (2.1) |
2178 (0.4) |
| Malignant cancer hospitalization2 |
0.0 |
10150 (7.2) |
0.0 |
19030 (7.2) |
41286 (8.3) |
42898 (8.2) |
| Severe bleeding hospitalization2 |
0.0 |
20484 (14.5) |
0.0 |
41975 (15.9) |
78804 (15.9) |
46030 (8.8) |
| Hyperkalemia hospitalization2 |
0.0 |
885 (0.6) |
0.0 |
2230 (0.8) |
3469 (0.7) |
404 (0.1) |
| Hypokalemia hospitalization2 |
0.0 |
468 (0.3) |
0.0 |
1147 (0.4) |
1854 (0.4) |
935 (0.2) |
| Syncope hospitalization2 |
0.0 |
3359 (2.4) |
0.0 |
7849 (3.0) |
14268 (2.9) |
9534 (1.8) |
| Trauma hospitalization2 |
0.0 |
18548 (13.1) |
0.0 |
36955 (14.0) |
79085 (15.9) |
62966 (12.0) |
| Coronary revascularization2 |
0.0 |
4453 (3.2) |
0.0 |
11343 (4.3) |
21774 (4.4) |
14097 (2.7) |
| Death2 |
0.0 |
80518 (57.0) |
0.0 |
142264 (53.9) |
356002 (71.6) |
136625 (26.1) |
| CV death2 |
0.0 |
46426 (32.9) |
0.0 |
83871 (31.8) |
205990 (41.5) |
40921 (7.8) |
| Non-CV death2 |
0.0 |
34092 (24.2) |
0.0 |
58393 (22.1) |
150012 (30.2) |
95704 (18.3) |
| Hospitalization or death Sudden cardiac death2 |
0.0 |
68 (0.0) |
0.0 |
123 (0.0) |
371 (0.1) |
97 (0.0) |
| Composite CVD/HFH2 |
0.0 |
64587 (45.8) |
0.0 |
129912 (49.2) |
285290 (57.4) |
40921 (7.8) |
| Composite Death/HFH2 |
0.0 |
88193 (62.5) |
0.0 |
163934 (62.1) |
385352 (77.6) |
136625 (26.1) |