Population
Patients registered in SwedeHF
All patients recorded in SwedeHF are included. This cohort includes patients up until 2023-12-31.
Patients with HF from the National Patient Register
Patients with an ICD-10 code for HF in main position in the National Patient Register (ICD-10: I110, I130, I132, I255, I420, I423, 1425-9, I43, I50, J81, K761) starting from 2000-01-01 with no previous ICD-9/10 code for HF (I110 I130 I132 I255 I420 I423 1425 I426 I427 I428 I429 I43 I50 J81 K761 ICD-9: 414W 425E 425F 425G 425H 425W 425X 428) since 1987. This cohort includes patients up until 2021-12-31.
HF-free controls
For each post in SwedeHF or the first date in the National Patient Register a set of controls was chosen by Statistics Sweden in a ratio of 2:1. Since a person can have more than one registered post in SwedeHF a patient can have more than 2 controls in total, up to 2 for each posts. This cohort includes patients up until 2021-12-31.
Eligible controls were persons without re-used Swedish personal identity numbers (PINs) and free of HF, defined either in the National Patient registry (ICD-10: I110, I130, I132, I255, I420, I423, 1425-9, I43, I50, J81, K761, R570, ICD-9: 414W, 425E-H, 425W, 425X, 428) or SwedeHF, at the end of the year of the index date for the case and matched by gender, year of birth and county of residence at index. For posts with age ≥ 90 years, controls were only matched by gender and year of birth due to the smaller available number of controls.
The selection of controls was performed without replacement.
A control was allowed to become a case after the year of the index date for the case.
A full set of controls (n = 2) was not found for all cases:
| Population | No controls | Posts | Unique patients |
|---|---|---|---|
| Case SwedeHF | 0 | 40426 | 19069 |
| Case SwedeHF | 1 | 17211 | 7319 |
| Case SwedeHF | 2 | 185576 | 104908 |
| Case NPR | 0 | 19187 | 19187 |
| Case NPR | 1 | 26442 | 26442 |
| Case NPR | 2 | 377463 | 377463 |
Inclusion/exclusion criteria
| Criteria | Case SwedeHF | Case NPR | Control SwedeHF | Control NPR |
|---|---|---|---|---|
| No of posts recieved | 246769 | 494514 | 405907 | 803243 |
| Exclude posts with duplicated index dates | 246146 | |||
| Exclude posts with with index date < 2000-01-01 | 246143 | 459841 | 405901 | 800473 |
| Exclude posts with with index date > 2023-12-31 (SwedeHF)/2021-12-31 (NPR HF, Controls) | 243917 | 426264 | 388934 | 785670 |
| Exclude posts < 18 years | 243900 | 424979 | 388907 | 783134 |
| Exclude posts that are not present in SCB register | 243489 | 423627 | 388907 | 783134 |
| Exclude posts with reused PINs | 243224 | 423251 | 388907 | 783134 |
| Exclude posts censored end fu < index | 243213 | 423092 | 388841 | 782402 |
| Exclude controls without cases | 243213 | 423092 | 388841 | 782402 |
| Exclude posts with end of follow-up <= index date (died in hospital) | 239931 | |||
| Unique patients | 129273 |