| n |
|
131296 |
|
243213 |
423092 |
388841 |
| ncontrols |
0.0 |
2.0 [1.0, 2.0] |
0.0 |
2.0 [2.0, 2.0] |
2.0 [2.0, 2.0] |
0.0 [0.0, 0.0] |
| Time in hospital at index hospitalization (days)1 |
64.7 |
5.0 [3.0, 9.0] |
68.2 |
5.0 [3.0, 9.0] |
|
|
| Index year1 |
0.0 |
2016.0 [2011.0, 2021.0] |
0.0 |
2016.0 [2011.0, 2020.0] |
2011.0 [2005.0, 2016.0] |
2014.0 [2010.0, 2018.0] |
| Type of visit Index1 |
0.0 |
76002 (57.9) |
0.0 |
132567 (54.5) |
|
|
| LVEF (%)1 |
82.0 |
40.0 [30.0, 50.0] |
82.4 |
40.0 [30.0, 45.0] |
|
|
| LVEF (%)1 |
21.0 |
|
18.6 |
|
|
|
| ≥50 |
|
27080 (26.1) |
|
44258 (22.4) |
|
|
| 40-49 |
|
25940 (25.0) |
|
47953 (24.2) |
|
|
| 30-39 |
|
26777 (25.8) |
|
53900 (27.2) |
|
|
| <30 |
|
23906 (23.1) |
|
51853 (26.2) |
|
|
| LVEF (%)1 |
21.0 |
|
18.6 |
|
|
|
| HFrEF (<40) |
|
50683 (48.9) |
|
105753 (53.4) |
|
|
| HFmrEF (40-49) |
|
25940 (25.0) |
|
47953 (24.2) |
|
|
| HFpEF (≥50) |
|
27080 (26.1) |
|
44258 (22.4) |
|
|
| Sex Male1 |
0.0 |
81474 (62.1) |
0.0 |
156846 (64.5) |
226530 (53.5) |
244108 (62.8) |
| Age (years)1 |
0.0 |
77.0 [69.0, 84.0] |
0.0 |
76.0 [67.0, 82.0] |
80.0 [71.0, 87.0] |
75.0 [67.0, 82.0] |
| Civil status Single1 |
27.5 |
42011 (44.1) |
27.0 |
73713 (41.5) |
|
|
| Living conditions Own home1 |
41.7 |
72630 (94.9) |
41.2 |
137784 (96.3) |
|
|
| Location In-patient1 |
0.0 |
46307 (35.3) |
0.0 |
77457 (31.8) |
|
|
| Smoking1 |
27.2 |
|
23.9 |
|
|
|
| Current |
|
10233 (10.7) |
|
19722 (10.7) |
|
|
| Former |
|
41979 (43.9) |
|
83063 (44.9) |
|
|
| Never |
|
43349 (45.4) |
|
82202 (44.4) |
|
|
| Smoking1 |
27.2 |
10233 (10.7) |
23.9 |
19722 (10.7) |
|
|
| Alcohol Risk1 |
41.4 |
3381 (4.4) |
37.8 |
6402 (4.2) |
|
|
| Duration of HF (months) ≥61 |
2.7 |
78710 (61.6) |
2.5 |
146331 (61.7) |
|
|
| Primary etiology1 |
39.2 |
|
38.4 |
|
|
|
| DCM |
|
5171 (6.5) |
|
12041 (8.0) |
|
|
| Heart valve disease |
|
6248 (7.8) |
|
10910 (7.3) |
|
|
| Hypertension |
|
20746 (26.0) |
|
37413 (25.0) |
|
|
| IHD |
|
30194 (37.8) |
|
58995 (39.4) |
|
|
| Known alcoholic cardiomyopathy |
|
532 (0.7) |
|
1066 (0.7) |
|
|
| Other |
|
16923 (21.2) |
|
29290 (19.6) |
|
|
| NYHA class1 |
28.6 |
|
24.6 |
|
|
|
| I |
|
13051 (13.9) |
|
23403 (12.8) |
|
|
| II |
|
43789 (46.7) |
|
89091 (48.6) |
|
|
| III |
|
33426 (35.6) |
|
65573 (35.7) |
|
|
| IV |
|
3514 (3.7) |
|
5375 (2.9) |
|
|
| NYHA class III-IV1 |
28.6 |
36940 (39.4) |
24.6 |
70948 (38.7) |
|
|
| Killip class1 |
94.0 |
|
95.5 |
|
|
|
| Chock or hypertension |
|
19 (0.2) |
|
41 (0.4) |
|
|
| Edema |
|
209 (2.7) |
|
285 (2.6) |
|
|
| No signs of HF |
|
3678 (46.7) |
|
5348 (48.6) |
|
|
| Rales or crackles |
|
3974 (50.4) |
|
5338 (48.5) |
|
|
| Weight (kg)1 |
14.5 |
77.6 [66.2, 90.0] |
13.3 |
79.0 [68.0, 92.0] |
|
|
| Weight at admission/visit (kg)1 |
31.8 |
78.0 [66.8, 90.8] |
35.0 |
79.5 [68.0, 92.0] |
|
|
| Weight at discharge (hospitalized patients) (kg)1 |
94.4 |
75.4 [63.9, 88.5] |
95.8 |
77.0 [65.2, 90.2] |
|
|
| Height (cm)1 |
29.6 |
172.0 [165.0, 179.0] |
24.2 |
173.0 [165.0, 180.0] |
|
|
| Systolic blood pressure (mmHg)1 |
4.5 |
125.0 [110.0, 140.0] |
3.9 |
125.0 [110.0, 140.0] |
|
|
| shf_bpsys_cat ≥1401 |
4.1 |
35036 (27.8) |
3.6 |
63411 (27.0) |
|
|
| Systolic blood pressure at admission/visit (mmHg)1 |
22.8 |
125.0 [111.0, 140.0] |
26.9 |
125.0 [111.0, 140.0] |
|
|
| Systolic blood pressure at discharge (hospitalized patients) (mmHg)1 |
93.5 |
125.0 [111.0, 140.0] |
95.2 |
124.0 [110.0, 140.0] |
|
|
| Diastolic blood pressure (mmHg)1 |
4.4 |
70.0 [65.0, 80.0] |
3.8 |
70.0 [65.0, 80.0] |
|
|
| Diastolic blood pressure at admission/visit (mmHg)1 |
22.7 |
72.0 [65.0, 80.0] |
26.8 |
72.0 [65.0, 80.0] |
|
|
| Diastolic blood pressure at discharge (hospitalized patients) (mmHg)1 |
93.5 |
72.0 [65.0, 80.0] |
95.2 |
72.0 [65.0, 80.0] |
|
|
| Mean arterial pressure (mmHg)1 |
4.4 |
90.0 [81.7, 99.3] |
3.8 |
90.0 [81.7, 98.7] |
|
|
| Mean arterial pressure (mmHg) >901 |
4.4 |
59534 (47.4) |
3.8 |
110609 (47.3) |
|
|
| Heart rate (beats/min)1 |
7.0 |
71.0 [62.0, 82.0] |
6.2 |
70.0 [62.0, 81.0] |
|
|
| Heart rate at admission/visit (beats/min)1 |
24.6 |
71.0 [63.0, 83.0] |
28.6 |
71.0 [62.0, 82.0] |
|
|
| Heart rate at discharge (hospitalized patients) (beats/min)1 |
93.8 |
74.0 [65.0, 85.0] |
95.3 |
74.0 [65.0, 85.0] |
|
|
| Heart rate (beats/min) >701 |
7.0 |
62063 (50.8) |
6.2 |
113881 (49.9) |
|
|
| Hemoglobin (g/L)1 |
9.5 |
132.0 [119.0, 144.0] |
9.5 |
133.0 [120.0, 145.0] |
|
|
| Hemoglobin at admission/visit (g/L)1 |
27.7 |
132.0 [119.0, 145.0] |
32.1 |
134.0 [121.0, 146.0] |
|
|
| Hemoglobin at discharge (hospitalized patients) (g/L)1 |
95.9 |
119.0 [106.0, 135.0] |
96.9 |
122.0 [108.0, 137.0] |
|
|
| Anemia1 |
9.5 |
43147 (36.3) |
9.4 |
74508 (33.8) |
|
|
| Potassium (mmol/L)1 |
18.3 |
4.2 [3.9, 4.5] |
16.9 |
4.2 [3.9, 4.5] |
|
|
| Potassium at admission/visit (mmol/L)1 |
32.2 |
4.2 [3.9, 4.5] |
35.0 |
4.2 [4.0, 4.5] |
|
|
| Potassium at discharge (hospitalized patients) (mmol/L)1 |
94.3 |
4.0 [3.7, 4.3] |
95.7 |
4.0 [3.7, 4.3] |
|
|
| Potassium (mmol/L)1 |
18.3 |
|
16.9 |
|
|
|
| 3.5-5 (Normakalemia) |
|
98417 (91.8) |
|
187190 (92.6) |
|
|
| <3.5 (Hypokalemia) |
|
4537 (4.2) |
|
7279 (3.6) |
|
|
| >5 (Hyperkalemia) |
|
4285 (4.0) |
|
7614 (3.8) |
|
|
| Sodium (mmol/L)1 |
31.4 |
140.0 [138.0, 142.0] |
31.1 |
140.0 [138.0, 142.0] |
|
|
| Sodium at admission/visit (mmol/L)1 |
41.7 |
140.0 [138.0, 142.0] |
44.2 |
140.0 [138.0, 142.0] |
|
|
| Sodium at discharge (hospitalized patients) (mmol/L)1 |
94.5 |
140.0 [138.0, 142.0] |
95.9 |
140.0 [138.0, 142.0] |
|
|
| Creatinine (µmol/L)1 |
3.8 |
97.0 [79.0, 125.0] |
3.5 |
96.0 [79.0, 122.0] |
|
|
| Creatinine at admission/visit (µmol/L)1 |
22.3 |
95.0 [78.0, 121.0] |
26.6 |
94.0 [77.0, 118.0] |
|
|
| Creatinine at discharge (hospitalized patients) (µmol/L)1 |
94.3 |
99.0 [78.0, 133.0] |
95.7 |
97.0 [78.0, 127.0] |
|
|
| eGFR (mL/min/1.73 m²)1 |
3.5 |
63.0 [45.3, 82.8] |
3.2 |
64.8 [47.2, 84.0] |
|
|
| eGFR (mL/min/1.73 m²) <601 |
3.5 |
57761 (45.6) |
3.2 |
101326 (43.0) |
|
|
| NT-proBNP (pg/mL)1 |
41.0 |
1908.0 [724.0, 4602.0] |
40.2 |
1812.0 [716.0, 4196.0] |
|
|
| NT-proBNP at admission/visit (pg/mL)1 |
50.1 |
1810.0 [682.0, 4315.0] |
51.7 |
1709.0 [669.0, 3921.0] |
|
|
| NT-proBNP at discharge (hospitalized patients) (pg/mL)1 |
97.7 |
3681.5 [1653.8, 8593.2] |
98.2 |
3388.0 [1530.0, 7540.0] |
|
|
| BNP (pg/mL)1 |
96.2 |
586.0 [224.0, 1352.5] |
95.8 |
529.0 [203.0, 1242.0] |
|
|
| Transferrin saturation (%)1 |
84.8 |
24.0 [17.0, 33.0] |
85.4 |
25.0 [17.0, 33.0] |
|
|
| Ferritin (µg/L)1 |
82.7 |
143.0 [71.0, 269.0] |
83.4 |
143.0 [71.0, 265.0] |
|
|
| QRS width (ms)1 |
22.2 |
104.0 [91.0, 134.0] |
22.2 |
106.0 [92.0, 136.0] |
|
|
| Left Bundle Branch Block (LBBB)1 |
22.8 |
17584 (17.3) |
23.0 |
34788 (18.6) |
|
|
| Loop diuretic IV1 |
77.8 |
6826 (23.4) |
78.0 |
9640 (18.0) |
|
|
| Ferric carboxymaltose IV1 |
49.6 |
3705 (5.6) |
50.8 |
6233 (5.2) |
|
|
| Ferric carboxymaltose IV dose (mg)1 |
97.3 |
1000.0 [1000.0, 1000.0] |
97.6 |
1000.0 [1000.0, 1000.0] |
|
|
| Unplanned inotrope support1 |
46.4 |
1416 (2.0) |
48.0 |
3772 (3.0) |
|
|
| Diuretic1 |
0.6 |
97144 (74.4) |
0.5 |
180927 (74.7) |
|
|
| Loop diuretic1 |
23.7 |
70551 (70.5) |
23.7 |
130817 (70.5) |
|
|
| Loop diuretic substance1 |
68.5 |
|
70.2 |
|
|
|
| Bumetanid |
|
278 (0.7) |
|
422 (0.6) |
|
|
| Furosemid |
|
40902 (98.9) |
|
71806 (99.0) |
|
|
| Toresamid |
|
182 (0.4) |
|
306 (0.4) |
|
|
| Loop diuretic dose (mg/24h)1 |
56.3 |
40.0 [40.0, 80.0] |
56.1 |
40.0 [40.0, 80.0] |
|
|
| Loop diuretic usage When necessary1 |
46.4 |
15887 (22.6) |
46.3 |
29789 (22.8) |
|
|
| ACEi1 |
0.5 |
59533 (45.6) |
0.4 |
115746 (47.8) |
|
|
| ACEi dose (mg/24h)1 |
54.7 |
10.0 [5.0, 15.0] |
52.5 |
10.0 [5.0, 15.0] |
|
|
| ARB1 |
1.0 |
36376 (28.0) |
0.8 |
71105 (29.5) |
|
|
| ARB dose (mg/24h)1 |
72.3 |
32.0 [12.5, 50.0] |
70.8 |
32.0 [12.5, 50.0] |
|
|
| ARNi1 |
48.4 |
11531 (17.0) |
49.8 |
21431 (17.5) |
|
|
| ACEi/ARB/ARNi1 |
1.1 |
105685 (81.4) |
0.9 |
204591 (84.9) |
|
|
| Beta-blocker1 |
0.5 |
112821 (86.3) |
0.3 |
213270 (88.0) |
|
|
| Beta-blocker dose (mg/24h)1 |
14.3 |
25.0 [5.0, 100.0] |
12.5 |
25.0 [5.0, 100.0] |
|
|
| MRA1 |
0.8 |
52972 (40.7) |
0.6 |
100969 (41.8) |
|
|
| MRA dose (mg/24h)1 |
70.4 |
25.0 [25.0, 25.0] |
70.3 |
25.0 [25.0, 25.0] |
|
|
| Digoxin1 |
0.5 |
15924 (12.2) |
0.4 |
29920 (12.4) |
|
|
| Platelet inhibitor1 |
0.6 |
48691 (37.3) |
0.4 |
90156 (37.2) |
|
|
| Oral anticoagulant1 |
0.5 |
62570 (47.9) |
0.4 |
119716 (49.4) |
|
|
| Statin1 |
0.5 |
62239 (47.6) |
0.4 |
121678 (50.2) |
|
|
| Nitrate1 |
0.6 |
15941 (12.2) |
0.5 |
28684 (11.8) |
|
|
| SGLT2i1 |
76.5 |
16712 (54.2) |
80.7 |
24348 (52.0) |
|
|
| SGLT2i substance1 |
87.3 |
|
90.0 |
|
|
|
| Dapagliflozin |
|
11508 (69.1) |
|
17074 (70.4) |
|
|
| Empagliflozin |
|
5136 (30.8) |
|
7164 (29.5) |
|
|
| Ertugliflozin |
|
10 (0.1) |
|
12 (0.0) |
|
|
| Kanagliflozin |
|
2 (0.0) |
|
2 (0.0) |
|
|
| SGLT2i dose (mg/24h)1 |
87.3 |
10.0 [10.0, 10.0] |
90.0 |
10.0 [10.0, 10.0] |
|
|
| Sinus node inhibitor1 |
50.4 |
296 (0.5) |
52.1 |
607 (0.5) |
|
|
| Device therapy1 |
1.2 |
|
1.5 |
|
|
|
| No |
|
107045 (82.5) |
|
193346 (80.7) |
|
|
| Pacemaker |
|
12046 (9.3) |
|
21990 (9.2) |
|
|
| CRT-P |
|
2493 (1.9) |
|
5248 (2.2) |
|
|
| CRT-D |
|
3944 (3.0) |
|
9419 (3.9) |
|
|
| ICD |
|
4163 (3.2) |
|
9539 (4.0) |
|
|
| Device therapy CRT/ICD1 |
1.2 |
10600 (8.2) |
1.5 |
24206 (10.1) |
|
|
| Chest X-ray1 |
39.9 |
|
38.6 |
|
|
|
| No |
|
23182 (29.4) |
|
46008 (30.8) |
|
|
| Normal |
|
18844 (23.9) |
|
35260 (23.6) |
|
|
| Pulmonary congestion |
|
10169 (12.9) |
|
17553 (11.7) |
|
|
| Cardiomegaly |
|
12278 (15.6) |
|
24341 (16.3) |
|
|
| Pulmonary congestion & cardiomegaly |
|
14372 (18.2) |
|
26263 (17.6) |
|
|
| Diabetes1 |
9.0 |
21793 (18.2) |
8.4 |
42621 (19.1) |
|
|
| Diabetes1 |
25.0 |
|
24.5 |
|
|
|
| No |
|
78747 (79.9) |
|
145792 (79.4) |
|
|
| Type I |
|
1498 (1.5) |
|
2670 (1.5) |
|
|
| Type II |
|
18292 (18.6) |
|
35065 (19.1) |
|
|
| Hypertension1 |
2.2 |
74390 (57.9) |
2.0 |
135513 (56.9) |
|
|
| Atrial fibrillation/flutter1 |
0.6 |
68053 (52.2) |
0.6 |
124178 (51.3) |
|
|
| Lung disease1 |
2.0 |
22546 (17.5) |
1.9 |
40401 (16.9) |
|
|
| Valve disease1 |
3.2 |
25076 (19.7) |
3.2 |
46211 (19.6) |
|
|
| Dilated cardiomyopathy1 |
4.3 |
12438 (9.9) |
4.4 |
28668 (12.3) |
|
|
| Revascularization1 |
2.8 |
33915 (26.6) |
3.0 |
67232 (28.5) |
|
|
| Valve surgery1 |
1.9 |
8571 (6.7) |
2.1 |
16526 (6.9) |
|
|
| ECG rythm1 |
8.5 |
|
8.1 |
|
|
|
| Sinus |
|
61073 (50.8) |
|
114461 (51.2) |
|
|
| Atrial fibrillation |
|
44721 (37.2) |
|
80484 (36.0) |
|
|
| PM/Other |
|
14360 (12.0) |
|
28469 (12.7) |
|
|
| Follow-up referral HF nurse clinic1 |
9.6 |
67597 (56.9) |
6.8 |
149167 (65.8) |
|
|
| Follow-up referral speciality1 |
7.6 |
|
5.3 |
|
|
|
| Hospital |
|
73801 (60.8) |
|
151600 (65.9) |
|
|
| Primary care |
|
42527 (35.1) |
|
70952 (30.8) |
|
|
| Other |
|
4977 (4.1) |
|
7653 (3.3) |
|
|
| Follow-up referral speciality Hospital1 |
7.6 |
73801 (60.8) |
5.3 |
151600 (65.9) |
|
|
| EQ5D-vas1 |
66.6 |
70.0 [50.0, 80.0] |
65.1 |
70.0 [50.0, 80.0] |
|
|
| EQ5D-vas1 |
66.6 |
|
65.1 |
|
|
|
| 0-25 |
|
1999 (4.6) |
|
3631 (4.3) |
|
|
| 26-50 |
|
10864 (24.8) |
|
20410 (24.1) |
|
|
| 51-75 |
|
17693 (40.4) |
|
34748 (41.0) |
|
|
| 76-100 |
|
13252 (30.3) |
|
25973 (30.6) |
|
|
| Fatigue1 |
57.3 |
|
55.4 |
|
|
|
| At rest |
|
3347 (6.0) |
|
5665 (5.2) |
|
|
| At moderate effort |
|
14974 (26.7) |
|
27922 (25.8) |
|
|
| At more than moderate effort |
|
28031 (50.0) |
|
56514 (52.2) |
|
|
| Unaffected |
|
9759 (17.4) |
|
18264 (16.9) |
|
|
| Out of breath1 |
56.8 |
|
55.0 |
|
|
|
| At rest |
|
1778 (3.1) |
|
2831 (2.6) |
|
|
| At moderate effort |
|
16415 (28.9) |
|
30715 (28.1) |
|
|
| At more than moderate effort |
|
29374 (51.8) |
|
59144 (54.0) |
|
|
| Unaffected |
|
9171 (16.2) |
|
16765 (15.3) |
|
|
| Mobilty1 |
56.7 |
|
55.0 |
|
|
|
| Bedridden |
|
652 (1.1) |
|
929 (0.8) |
|
|
| Some problem |
|
25214 (44.3) |
|
45942 (42.0) |
|
|
| No problem |
|
31019 (54.5) |
|
62555 (57.2) |
|
|
| Hygiene1 |
57.1 |
|
55.4 |
|
|
|
| Can't wash and clothe |
|
1070 (1.9) |
|
1494 (1.4) |
|
|
| Some problem |
|
6341 (11.3) |
|
10305 (9.5) |
|
|
| No problem |
|
48869 (86.8) |
|
96721 (89.1) |
|
|
| Main activities1 |
57.3 |
|
55.6 |
|
|
|
| Can't do |
|
2770 (4.9) |
|
4434 (4.1) |
|
|
| Some problem |
|
14801 (26.4) |
|
27180 (25.2) |
|
|
| No problem |
|
38437 (68.6) |
|
76394 (70.7) |
|
|
| Pain1 |
59.1 |
|
57.2 |
|
|
|
| Severe |
|
3420 (6.4) |
|
6100 (5.9) |
|
|
| Moderate |
|
24197 (45.1) |
|
46814 (45.0) |
|
|
| None |
|
26063 (48.6) |
|
51192 (49.2) |
|
|
| Anxiety/Depression1 |
60.8 |
|
58.9 |
|
|
|
| Severe |
|
2196 (4.3) |
|
3910 (3.9) |
|
|
| Moderate |
|
18783 (36.4) |
|
36213 (36.2) |
|
|
| None |
|
30553 (59.3) |
|
59869 (59.9) |
|
|
| BMI (kg/m²)1 |
37.6 |
26.3 [23.3, 30.2] |
32.2 |
26.7 [23.6, 30.5] |
|
|
| BMI (kg/m²) ≥301 |
37.6 |
21533 (26.3) |
32.2 |
46197 (28.0) |
|
|
| Target dose beta-blocker (%)1 |
14.3 |
50.0 [25.0, 100.0] |
12.5 |
50.0 [25.0, 100.0] |
|
|
| Target dose beta-blocker (%)1 |
0.7 |
|
0.6 |
|
|
|
| 0 |
|
17873 (13.7) |
|
29102 (12.0) |
|
|
| 1-49 |
|
40274 (30.9) |
|
74526 (30.8) |
|
|
| 50-99 |
|
39502 (30.3) |
|
75396 (31.2) |
|
|
| ≥100 |
|
32759 (25.1) |
|
62819 (26.0) |
|
|
| Target dose MRA (%)1 |
70.4 |
50.0 [50.0, 50.0] |
70.3 |
50.0 [50.0, 50.0] |
|
|
| Target dose MRA (%)1 |
11.5 |
|
12.4 |
|
|
|
| 0 |
|
77326 (66.5) |
|
140861 (66.1) |
|
|
| 1-49 |
|
4563 (3.9) |
|
8712 (4.1) |
|
|
| 50-99 |
|
26812 (23.1) |
|
50192 (23.6) |
|
|
| ≥100 |
|
7515 (6.5) |
|
13322 (6.3) |
|
|
| Target dose ACEi (%)1 |
54.7 |
50.0 [25.0, 75.0] |
52.5 |
50.0 [25.0, 75.0] |
|
|
| Target dose ACEi (%)1 |
0.6 |
|
0.5 |
|
|
|
| 0 |
|
71096 (54.5) |
|
126532 (52.3) |
|
|
| 1-49 |
|
24044 (18.4) |
|
44619 (18.4) |
|
|
| 50-99 |
|
21788 (16.7) |
|
43014 (17.8) |
|
|
| ≥100 |
|
13591 (10.4) |
|
27912 (11.5) |
|
|
| Target dose ARB (%)1 |
72.3 |
50.0 [25.0, 75.0] |
70.8 |
50.0 [25.0, 75.0] |
|
|
| Target dose ARB (%)1 |
1.0 |
|
0.8 |
|
|
|
| 0 |
|
93624 (72.1) |
|
170155 (70.6) |
|
|
| 1-49 |
|
16000 (12.3) |
|
30723 (12.7) |
|
|
| 50-99 |
|
11448 (8.8) |
|
22792 (9.5) |
|
|
| ≥100 |
|
8871 (6.8) |
|
17481 (7.2) |
|
|
| Target dose ARNi (%)1 |
91.2 |
75.0 [50.0, 100.0] |
91.2 |
62.0 [50.0, 100.0] |
|
|
| Target dose ARNi (%)1 |
48.5 |
|
49.8 |
|
|
|
| 0 |
|
56209 (83.1) |
|
100792 (82.5) |
|
|
| 1-49 |
|
2507 (3.7) |
|
4759 (3.9) |
|
|
| 50-99 |
|
3482 (5.1) |
|
6930 (5.7) |
|
|
| ≥100 |
|
5478 (8.1) |
|
9640 (7.9) |
|
|
| Target dose ACEi/ARB/ARNi (%)1 |
19.1 |
50.0 [25.0, 100.0] |
15.6 |
50.0 [25.0, 100.0] |
|
|
| Target dose ACEi/ARB/ARNi (%)1 |
0.8 |
|
0.6 |
|
|
|
| 0 |
|
24174 (18.6) |
|
36440 (15.1) |
|
|
| 1-49 |
|
41987 (32.2) |
|
78779 (32.6) |
|
|
| 50-99 |
|
36347 (27.9) |
|
71838 (29.7) |
|
|
| ≥100 |
|
27803 (21.3) |
|
54730 (22.6) |
|
|
| Age (years)1 |
0.0 |
|
0.0 |
|
|
|
| <70 |
|
35535 (27.1) |
|
74944 (30.8) |
92641 (21.9) |
125513 (32.3) |
| 70-80 |
|
45907 (35.0) |
|
89695 (36.9) |
126149 (29.8) |
148749 (38.3) |
| >80 |
|
49854 (38.0) |
|
78574 (32.3) |
204302 (48.3) |
114579 (29.5) |
| Previous HFH < 1 year12 |
0.0 |
71533 (54.5) |
0.0 |
125975 (51.8) |
287418 (67.9) |
0 (0.0) |
| Atrial fibrillation/flutter12 |
0.0 |
77385 (58.9) |
0.0 |
140804 (57.9) |
186715 (44.1) |
26067 (6.7) |
| IHD12 |
0.0 |
69045 (52.6) |
0.0 |
129462 (53.2) |
191822 (45.3) |
50546 (13.0) |
| Hypertension12 |
0.0 |
89864 (68.4) |
0.0 |
163366 (67.2) |
218334 (51.6) |
83462 (21.5) |
| Diabetes12 |
0.0 |
35817 (27.3) |
0.0 |
66979 (27.5) |
96547 (22.8) |
31970 (8.2) |
| Valve disease12 |
0.0 |
34649 (26.4) |
0.0 |
63760 (26.2) |
64209 (15.2) |
7756 (2.0) |
| Country of birth3 |
0.0 |
|
0.0 |
|
|
|
| Sweden |
|
112782 (85.9) |
|
207034 (85.1) |
370470 (87.6) |
338661 (87.1) |
| Europe |
|
14219 (10.8) |
|
27671 (11.4) |
42128 (10.0) |
37015 (9.5) |
| Other |
|
4292 (3.3) |
|
8503 (3.5) |
10483 (2.5) |
13134 (3.4) |
| Children3 |
0.0 |
109929 (83.7) |
0.0 |
203482 (83.7) |
350591 (82.9) |
329159 (84.7) |
| Marital status Single/widowed/divorced3 |
0.1 |
71010 (54.1) |
0.1 |
126939 (52.2) |
246572 (58.4) |
183021 (47.1) |
| Family situation Living alone3 |
0.1 |
65880 (50.2) |
0.1 |
116595 (48.0) |
232400 (55.0) |
168465 (43.4) |
| Education3 |
2.0 |
|
1.9 |
|
|
|
| Compulsory school |
|
54780 (42.6) |
|
98733 (41.4) |
206723 (51.1) |
145478 (38.1) |
| Secondary school |
|
50807 (39.5) |
|
96407 (40.4) |
140379 (34.7) |
147188 (38.5) |
| University |
|
23039 (17.9) |
|
43351 (18.2) |
57768 (14.3) |
89225 (23.4) |
| Disposable income (100 SEK)3 |
0.1 |
1607.0 [1266.0, 2193.0] |
0.1 |
1620.0 [1276.0, 2236.0] |
1370.0 [1058.0, 1790.0] |
1659.0 [1273.0, 2484.0] |
| Duration of HF (days)2 |
0.0 |
307.0 [17.0, 1734.0] |
0.0 |
336.0 [20.0, 1866.0] |
0.0 [0.0, 101.0] |
|
| Time since last HF hospitalization (days)2 |
43.0 |
25.0 [0.0, 312.0] |
42.9 |
29.0 [0.0, 352.0] |
0.0 [0.0, 0.0] |
|
| Location2 |
0.0 |
|
0.0 |
|
|
|
| HF in-patient |
|
30437 (23.2) |
|
52980 (21.8) |
287418 (67.9) |
|
| Other in-patient |
|
17026 (13.0) |
|
26259 (10.8) |
13888 (3.3) |
|
| Out-patient |
|
83833 (63.9) |
|
163974 (67.4) |
121786 (28.8) |
|
| Hypertension2 |
0.0 |
78237 (59.6) |
0.0 |
140966 (58.0) |
218334 (51.6) |
83462 (21.5) |
| Diabetes2 |
0.0 |
34289 (26.1) |
0.0 |
63765 (26.2) |
96547 (22.8) |
31970 (8.2) |
| Ischemic heart disease2 |
0.0 |
67708 (51.6) |
0.0 |
126796 (52.1) |
190206 (45.0) |
50213 (12.9) |
| Myocardial infarction2 |
0.0 |
49397 (37.6) |
0.0 |
92697 (38.1) |
130322 (30.8) |
27023 (6.9) |
| Angina pectoris2 |
0.0 |
23770 (18.1) |
0.0 |
45290 (18.6) |
77064 (18.2) |
15462 (4.0) |
| PCI2 |
0.0 |
25772 (19.6) |
0.0 |
50287 (20.7) |
47533 (11.2) |
16449 (4.2) |
| CABG2 |
0.0 |
33232 (25.3) |
0.0 |
65348 (26.9) |
66035 (15.6) |
20004 (5.1) |
| Dilated cardiomyopathy2 |
0.0 |
11213 (8.5) |
0.0 |
25905 (10.7) |
13653 (3.2) |
0 (0.0) |
| Peripheral artery disease2 |
0.0 |
12548 (9.6) |
0.0 |
21898 (9.0) |
34585 (8.2) |
10077 (2.6) |
| Atrial fibrillation/flutter2 |
0.0 |
72003 (54.8) |
0.0 |
130554 (53.7) |
186715 (44.1) |
26067 (6.7) |
| Stroke2 |
0.0 |
20359 (15.5) |
0.0 |
35032 (14.4) |
70443 (16.6) |
33723 (8.7) |
| TIA2 |
0.0 |
4615 (3.5) |
0.0 |
8124 (3.3) |
15554 (3.7) |
8387 (2.2) |
| Stroke/TIA2 |
0.0 |
23199 (17.7) |
0.0 |
40138 (16.5) |
79974 (18.9) |
39439 (10.1) |
| Valvular disease2 |
0.0 |
27285 (20.8) |
0.0 |
49504 (20.4) |
64209 (15.2) |
7756 (2.0) |
| Renal failure2 |
0.0 |
20378 (15.5) |
0.0 |
34618 (14.2) |
45714 (10.8) |
6955 (1.8) |
| Dialysis2 |
0.0 |
1248 (1.0) |
0.0 |
2010 (0.8) |
4356 (1.0) |
638 (0.2) |
| Hyperkalemia2 |
0.0 |
2972 (2.3) |
0.0 |
5123 (2.1) |
4709 (1.1) |
602 (0.2) |
| Hypokalemia2 |
0.0 |
3921 (3.0) |
0.0 |
6421 (2.6) |
9887 (2.3) |
2081 (0.5) |
| COPD2 |
0.0 |
18139 (13.8) |
0.0 |
32305 (13.3) |
51046 (12.1) |
10677 (2.7) |
| Pneumonia/Flue/Respiratory infection2 |
0.0 |
47426 (36.1) |
0.0 |
84347 (34.7) |
151625 (35.8) |
36288 (9.3) |
| Liver disease2 |
0.0 |
3076 (2.3) |
0.0 |
5564 (2.3) |
7976 (1.9) |
2682 (0.7) |
| Obstructive sleep apnea2 |
0.0 |
5992 (4.6) |
0.0 |
11855 (4.9) |
10754 (2.5) |
5489 (1.4) |
| Dementia2 |
0.0 |
3217 (2.5) |
0.0 |
4128 (1.7) |
18786 (4.4) |
13965 (3.6) |
| Depression2 |
0.0 |
4901 (3.7) |
0.0 |
8669 (3.6) |
15516 (3.7) |
8932 (2.3) |
| Malignant cancer2 |
0.0 |
17684 (13.5) |
0.0 |
31033 (12.8) |
54656 (12.9) |
43065 (11.1) |
| Muscoloskeletal diseases2 |
0.0 |
42672 (32.5) |
0.0 |
77289 (31.8) |
124143 (29.3) |
77650 (20.0) |
| Alcohol abuse2 |
0.0 |
4304 (3.3) |
0.0 |
7896 (3.2) |
10905 (2.6) |
5620 (1.4) |
| Severe bleeding2 |
0.0 |
26017 (19.8) |
0.0 |
45062 (18.5) |
72078 (17.0) |
26954 (6.9) |
| Charlson Comorbidity Index2 |
0.0 |
3.0 [2.0, 4.0] |
0.0 |
3.0 [1.0, 4.0] |
2.0 [1.0, 4.0] |
0.0 [0.0, 2.0] |
| Charlson Comorbidity Index age-adjusted2 |
0.0 |
6.0 [5.0, 8.0] |
0.0 |
6.0 [4.0, 7.0] |
6.0 [5.0, 7.0] |
4.0 [2.0, 5.0] |
| Charlson Comorbidity Index2 |
0.0 |
|
0.0 |
|
|
|
| 0-1 |
|
31969 (24.3) |
|
62378 (25.6) |
116632 (27.6) |
283820 (73.0) |
| 2-3 |
|
52454 (40.0) |
|
99073 (40.7) |
179391 (42.4) |
83214 (21.4) |
| 4-7 |
|
41110 (31.3) |
|
72399 (29.8) |
114013 (26.9) |
20289 (5.2) |
| ≥8 |
|
5763 (4.4) |
|
9363 (3.8) |
13056 (3.1) |
1518 (0.4) |
| SGLT2i2 |
0.0 |
17486 (13.3) |
0.0 |
26476 (10.9) |
2962 (0.7) |
1492 (0.4) |
| GLP1a2 |
0.0 |
2198 (1.7) |
0.0 |
3956 (1.6) |
2021 (0.5) |
1484 (0.4) |
| Heart failure hospitalization2 |
0.0 |
35847 (27.3) |
0.0 |
88583 (36.4) |
154521 (36.5) |
0 (0.0) |
| Number of heart failure hospitalizations2 |
0.0 |
0.0 [0.0, 1.0] |
0.0 |
0.0 [0.0, 1.0] |
0.0 [0.0, 1.0] |
0.0 [0.0, 0.0] |
| Any hospitalization2 |
0.0 |
90973 (69.3) |
0.0 |
180540 (74.2) |
336727 (79.6) |
233844 (60.1) |
| CV hospitalization2 |
0.0 |
59706 (45.5) |
0.0 |
129778 (53.4) |
239030 (56.5) |
80064 (20.6) |
| Non-CV hospitalization2 |
0.0 |
73691 (56.1) |
0.0 |
146058 (60.1) |
280667 (66.3) |
210453 (54.1) |
| Stroke/TIA hospitalization2 |
0.0 |
9772 (7.4) |
0.0 |
19129 (7.9) |
43120 (10.2) |
34197 (8.8) |
| Myocardial infarction hospitalization2 |
0.0 |
6670 (5.1) |
0.0 |
14237 (5.9) |
36231 (8.6) |
12763 (3.3) |
| Ischemic heart disease hospitalization2 |
0.0 |
11710 (8.9) |
0.0 |
27034 (11.1) |
58352 (13.8) |
18550 (4.8) |
| Ventricular fibrillation/tachycardia hospitalization2 |
0.0 |
1602 (1.2) |
0.0 |
4944 (2.0) |
5331 (1.3) |
280 (0.1) |
| Pneumonia/Flue/Respiratory infection hospitalization2 |
0.0 |
22320 (17.0) |
0.0 |
45615 (18.8) |
96521 (22.8) |
36187 (9.3) |
| Pneumonia hospitalization2 |
0.0 |
14956 (11.4) |
0.0 |
30752 (12.6) |
63889 (15.1) |
27257 (7.0) |
| Acute renal failure hospitalization2 |
0.0 |
6401 (4.9) |
0.0 |
13716 (5.6) |
21857 (5.2) |
5097 (1.3) |
| End-stage renal failure2 |
0.0 |
2410 (1.8) |
0.0 |
5003 (2.1) |
9217 (2.2) |
1894 (0.5) |
| Malignant cancer hospitalization2 |
0.0 |
9373 (7.1) |
0.0 |
17382 (7.1) |
37916 (9.0) |
43452 (11.2) |
| Severe bleeding hospitalization2 |
0.0 |
18992 (14.5) |
0.0 |
38523 (15.8) |
71480 (16.9) |
39678 (10.2) |
| Hyperkalemia hospitalization2 |
0.0 |
813 (0.6) |
0.0 |
2039 (0.8) |
3114 (0.7) |
305 (0.1) |
| Hypokalemia hospitalization2 |
0.0 |
413 (0.3) |
0.0 |
1015 (0.4) |
1578 (0.4) |
726 (0.2) |
| Syncope hospitalization2 |
0.0 |
3099 (2.4) |
0.0 |
7207 (3.0) |
13159 (3.1) |
7720 (2.0) |
| Trauma hospitalization2 |
0.0 |
17150 (13.1) |
0.0 |
33655 (13.8) |
72554 (17.1) |
53453 (13.7) |
| Coronary revascularization2 |
0.0 |
4212 (3.2) |
0.0 |
10582 (4.4) |
20177 (4.8) |
10766 (2.8) |
| Death2 |
0.0 |
75141 (57.2) |
0.0 |
131849 (54.2) |
326980 (77.3) |
148054 (38.1) |
| CV death2 |
0.0 |
43797 (33.4) |
0.0 |
78681 (32.4) |
190988 (45.1) |
45367 (11.7) |
| Non-CV death2 |
0.0 |
31344 (23.9) |
0.0 |
53168 (21.9) |
135992 (32.1) |
102687 (26.4) |
| Hospitalization or death Sudden cardiac death2 |
0.0 |
64 (0.0) |
0.0 |
118 (0.0) |
357 (0.1) |
113 (0.0) |
| Composite CVD/HFH2 |
0.0 |
60779 (46.3) |
0.0 |
121798 (50.1) |
261346 (61.8) |
45367 (11.7) |
| Composite Death/HFH2 |
0.0 |
82530 (62.9) |
0.0 |
152709 (62.8) |
351416 (83.1) |
148054 (38.1) |